Keselamatan dari Mitsubishi Xpander adalah sebagai berikut:
| Varian | Mitsubishi Xpander Cross 2020 MT | Mitsubishi Xpander Cross 2020 AT | Mitsubishi Xpander Cross 2020 Premium Package AT | Mitsubishi Xpander GLX M/T | Mitsubishi Xpander Cross MT | Mitsubishi Xpander Cross AT | Mitsubishi Xpander Cross Premium Package AT | Mitsubishi Xpander Limited Limited A/T | Mitsubishi Xpander GLS M/T | Mitsubishi Xpander Exceed M/T | Mitsubishi Xpander GLS A/T | Mitsubishi Xpander Exceed A/T | Mitsubishi Xpander Sport M/T | Mitsubishi Xpander Sport A/T | Mitsubishi Xpander Ultimate A/T |
| Peringkat Euro NCAP | |||||||||||||||
| Peringkat ASEAN NCAP | |||||||||||||||
| Jumlah airbag | |||||||||||||||
| Airbag kursi penumpang / utama | |||||||||||||||
| Airbag sisi depan / belakang | |||||||||||||||
| Airbag lutut | |||||||||||||||
| Pengingat sabuk pengaman | |||||||||||||||
| Active emergency braking system | |||||||||||||||
| Tire Pressure Monitoring System (TPMS) | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N |
| Lane Departure Warning System (LDWS) | |||||||||||||||
| Lane Keeping Assist System (LKAS) | |||||||||||||||
| Collision avoidance system(CAS) | |||||||||||||||
| Anti-lock Braking System (ABS) | |||||||||||||||
| Electronic Brake-force Distribution (EBD) | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| Sistem kontrol traksi | |||||||||||||||
| Vehicle Stability Control (VSC) | |||||||||||||||
| Child safety lock | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| ISOFIX | |||||||||||||||
| Security alert | |||||||||||||||
| Immobilizer | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y |
