Ya, Mercedes-Benz E-Class memiliki Child safety lock, yaitu: Mercedes-Benz E-Class E 200 Avantgarde Line, Mercedes-Benz E-Class E 300 SportStyle Avantgarde Line, Mercedes-Benz E-Class E 350 AMG Line, Mercedes-Benz E-Class E 300 Coupe AMG Line, Mercedes-Benz E-Class AMG E 43 4MATIC, Mercedes-Benz E-Class E300e AMG Line, Mercedes-Benz E-Class AMG E 63 S 4MATIC+.